Preparing scientists to explore the molecules in complex living systems and how molecules influence health and disease
Director Jason Gestwicki, PhD
Roles
- Director, Chemistry and Chemical Biology Graduate Program
- Professor, Department of Pharmaceutical Chemistry, UCSF School of Pharmacy
- Professor, Institute for Neurodegenerative Diseases
Faculty affiliations
- California Institute for Quantitative Biosciences (QB3) at UCSF
- Helen Diller Family Comprehensive Cancer Center
About my research
Research in the Gestwicki Lab studies how molecular chaperones maintain protein homeostasis. This question is important because imbalances in protein homeostasis are linked to a number of incurable diseases, including neurodegenerative disorders. Molecular chaperones regulate all aspects of a protein’s lifecycle, including its expression, folding, trafficking and degradation. However, it isn’t yet clear how we might promote the activity of chaperones to cure diseases. Our approach to this question is to develop chemical probes that reveal how chaperones interact with disease-associated proteins.
Contact info
Neuroscience Research Building Box 0518
675 Nelson Rising Ln Rm 311
San Francisco CA 94143
FedEx only: use zip 94158
415-502-7121
