Courses and Course Materials
Listed below are all course requirements for the Chemistry and Chemical Biology Graduate Program including course name and number, quarters offered, units, and instructors.
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Required core courses
BP 204 A and B: Macromolecular Structure and Interactions
4 units each
Robert Stroud and Andrej Sali in Fall, John Gross, James Fraser, and Klim Verba in Winter
BP 204A: This is a team-based class where students work in small groups develop their own analysis of real data that they have collected. The course will function in three modules. In module 1 “data collection” students collect either NMR, negative stain EM, and X-ray crystallographic data. In module 2 “fundamentals of analysis,” students will are mixed into new groups for lectures and hands-on computational tutorials. These lessons emphasize connections to both the molecular interpretations and the fundamental physical principles that generated the data. In module 3 “integrative structural biology,” the students will finalize their analysis and lectures will emphasize computational frameworks for integrative structural modeling. Finally, each group will present to their findings to the class and course faculty.
BP 204B: In this course, we will pursue a qualitative and quantitative understanding of the physical basis of macromolecular function. We will examine: the nature and quantification of the forces that drive macromolecular interactions, both intramolecular (macromolecular folding), and with other proteins and ligands; diffusion of macromolecules; the structural underpinnings of the kinetics and thermodynamics of macromolecular reactions; and the physical basis of important biophysical methods. We will examine the distinctions for macromolecules residing in lipid bilayers. The classwork will be mostly interactive with a weekly lecture that informs in class problem solving and discussion of relevant classic and current literature.
CHEM 243: Chemical Biology
Charles S. Craik
This survey course is team-taught and designed to illustrate the use of chemical approaches to investigate biological processes at the biochemical, the cellular, and the organismal levels.
CHEM 244: Reaction Mechanisms
This course is designed to develop knowledge of organic reaction mechanisms. This interactive course involves some lectures, but enforces student learning through intensive arrow-pushing sessions with students at the board. Current topics include: electrocyclic reactions, Woodward-Hoffman rules, sigmatropic reactions, migration reactions, neighboring group effects, carbanions and free radicals, carbenes, carbenoids, nitrenes, six-membered heterocyclic rings, five-membered heterocyclic rings.
Other required courses
CHEM 206: Laboratory Rotation
Fall/winter/spring, first year only
CHEM 219: Special Topics in Chemical Biology (mini courses)
UCSF Basic Science Graduate Programs collaborate to offer elective courses that allow for diversification of curriculum. Students are expected to take at least one mini course outside the Chemistry and Chemical Biology Program.
CHEM 221: Seminar Program (BBC Seminar Series)
Selected topics by guest lecturers
CHEM 223: CCB Student Seminar Program
This seminar provides graduate students with a forum in which to develop seminar and poster presentation skills, critically organize and critically review scientific data, and analyze and question oral scientific presentations.
CHEM 225: Graduate Research Opportunities (BBC Pizza Talks)
Fall/winter, first year only
This course offers first-year students a series of weekly presentations on research interests of basic science faculty. The purpose is to acquaint new graduate students with research projects and opportunities in faculty laboratories.
CHEM 297: QBC Journal Club
1 unit each
QBC Journal Club, critical review of published scientific papers from scholarly journals, including comprehension, analysis, and evaluation of published scientific data.
CHEM 250: Research
CHEM 266: Research Planning Conference
Discussion and practice in research problem formulation and design selection. Core classes and small group sessions are organized around students' interests by faculty within the area of specialization.
Graduate 202: Race and Racism in Science
Graduate 214: Ethics and the Responsible Conduct of Research
Spring first year, eight sessions
Sessions cover data management, animals in research, human subjects in research, rules and etiquette of publications, procedures and rules of grants, corporate-academic interactions.