David Agard

[email protected]

Professor, Biochemistry & Biophysics

Research summary: Structure, function, and folding of proteins, chromosomes, and centrosomes

http://www.msg.ucsf.edu/agard

Michelle Arkin

[email protected]

Professor and Chair, Pharmaceutical Chemistry; Co-Director, Small Molecule Discovery Center, Pharmaceutical Chemistry

Research summary: Chemical biology of protein-protein interactions and small-molecule drug discovery using biophysical and biological approaches

https://pharm.ucsf.edu/arkin

Peter Bruno

[email protected]

Assistant Professor, Urology & Cellular & Molecular Pharmacology

Research summary: We explore the fundamental rules governing antigen presentation and T-cell recognition, chemotherapy mechanisms of action, and cellular senescence.

https://brunolabucsf.com

Al Burlingame

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Protein Machines, Posttranslational Dynamics and Mass Spectrometry

http://msf.ucsf.edu/

Yifan Cheng

[email protected]

Professor, Biochemistry & Biophysics

Research summary: Using molecular electron microscopy as a tool to study structural and functional characterizations of macromolecules assemblies, including endocytotic machinery, clathrin coated vesicles, and protein degradation machinery, proteasome.

http://cryoem.ucsf.edu

John Chorba

[email protected]

Assistant Professor, Medicine, Medicine

Research summary: Developing chemical and biochemical tools to understand the molecular mechanisms of cardio metabolic disease and develop novel therapies

https://chorbalab.ucsf.edu

Willow Coyote-Maestas

[email protected]

Assistant Professor, Bioengineering & Therapeutic Sciences

Research summary: High throughput quantitative approaches for studying membrane proteins folding, function, and trafficking and how mutations tune these processes in evolution and disease. (Students co-mentored by faculty in program.)

https://www.wcoyotelab.com/

Charles Craik

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Protein engineering, mutagenesis, heterologous gene expression, enzyme mechanisms and inhibitor design.

https://pharm.ucsf.edu/craik

Bill DeGrado

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Molecular design as an approach to understanding macromolecule structure and function.

https://pharm.ucsf.edu/degrado

Nicole DelRosso

[email protected]

Sandler Faculty Fellow, Cellular & Molecular Pharmacology

Research summary: Developing high-throughput methods to measure and manipulate protein interactions in human gene regulation.

https://www.delrossolab.com/

Joseph DeRisi

[email protected]

Professor, Biochemistry & Biophysics

Research summary: Infectious Disease, Genomics

https://derisilab.ucsf.edu

Pamela England

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Ion channel structure-function, synaptic plasticity.

http://englandlab.ucsf.edu/

Michael Evans

[email protected]

Assistant Professor, Radiology & Biomedical Imaging

Research summary: Discovery and application of new biomarkers in oncology with molecular imaging

http://profiles.ucsf.edu/michael.evans

Alan Frankel

[email protected]

Professor, Biochemistry & Biophysics

Research summary: Assembly and function of RNA-protein complexes; structure and mechanisms of HIV Tat and Rev; HIV-host protein interactions

https://frankellab.ucsf.edu/

James Fraser

[email protected]

Professor and Chair, Bioengineering and Therapeutic Sciences Department, Bioengineering & Therapeutic Sciences

Research summary: Determining how engineering protein conformational ensembles change in response to chemical, physical, and genetic perturbations using structural, computational, and evolutionary approaches

https://fraserlab.com/

Danica Galonic Fujimori

[email protected]

Professor, Cellular & Molecular Pharmacology

Research summary: Chemical approaches to investigate enzymatic function

http://fujimorilab.ucsf.edu

Zev Gartner

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Physical and chemical basis of tissue self-organization and cell-cell interactions

https://gartnerlab.ucsf.edu/

Jason Gestwicki

[email protected]

Associate Professor in Residence, Institute for Neurodegenerative Diseases

Research summary: Targeting protein-protein interactions in the molecular chaperone complexes to understand protein homeostasis and treat protein misfolding diseases

https://ind.ucsf.edu/our-people/jason-gestwicki-phd

John Gross

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Structural biology and mechanism of gene specific translation control; RNA turnover; macromolecular NMR spectroscopy.

https://grosslab.ucsf.edu

Bo Huang

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Developing fluorescent probes and optical microscopy techniques for the investigation of genome organization and compartmentalization of cell signaling.

http://huanglab.ucsf.edu

Roshanak Irannejad

[email protected]

Assistant Professor, Cardiovascular Research Institute, Biochemistry & Biophysics

Research summary: Spatial Aspects of Signaling

http://irannejadlab.ucsf.edu/

David Julius

[email protected]

Professor, Physiology

Research summary: The Molecular Biology of Nociception and Pain

http://physio.ucsf.edu/julius/

Young-Wook Jun

[email protected]

Associate Professor, Otolaryngology

Research summary: Nano-bio science to understand and/or to manipulate biomolecular dynamics at the single molecule level

http://junlab.ucsf.edu/

Natalia Jura

[email protected]

Professor, Cellular & Molecular Pharmacology

Research summary: Structural basis for Receptor Tyrosine Kinase signaling across the plasma membrane and its regulation by actin cytoskeleton

https://cvri.ucsf.edu/people/natalia-jura-phd

Martin Kampmann

[email protected]

Professor, Biochemistry & Biophysics

Research summary: We integrate CRISPR-based functional genomics in human iPSC-derived cell types & bioinformatics with mechanistic biochemistry & biophysics to identify disease mechanisms & therapeutic targets. Major areas of interest: Neurodegeneration, protein homeostasis, cell type-specific functions of genes, pathways and organelles.

http://kampmannlab.ucsf.edu

Tanja Kortemme

[email protected]

Professor, Bioengineering & Therapeutic Sciences

Research summary: Computational biology, prediction and design of protein interactions and networks, synthetic biology

http://kortemmelab.ucsf.edu/

Nevan Krogan

[email protected]

Professor, Cellular & Molecular Pharmacology

Research summary: Functional Insights from Genetic and Physical Interaction Maps

http://kroganlab.ucsf.edu

Wendell Lim

[email protected]

Professor, Cellular & Molecular Pharmacology

Research summary: Structure-function studies of potassium channels in mammalian heart and hippocampus.

http://limlab.ucsf.edu/

Kevin Lou

[email protected]

QBI Faculty Fellow, Cellular & Molecular Pharmacology

Research summary: Molecular logic in drug design; synthetic chemistry; functional genomics

Aashish Manglik

[email protected]

Associate Professor, Pharmaceutical Chemistry

Research summary: Molecular basis of transmembrane signaling using integrative techniques in structural biology, biophysics, pharmacology, and protein engineering.

http://www.mangliklab.com

Daniel Minor

[email protected]

Professor, Cardiovascular Research Institute

Research summary: Molecular Basis of electrical signaling; Ion channel structure, function, and modulation. Membrane protein structure.

https://cvri.ucsf.edu/people/daniel-minor-phd

Geeta Narlikar

[email protected]

Professor, Biochemistry & Biophysics

Research summary: Mechanisms of chromatin remodeling

https://narlikarlab.ucsf.edu

Jonathan Ostrem

[email protected]

Assistant Professor, Hematology/Oncology

Research summary: Novel chemical approaches for cancer treatment; challenging drug targets and overcoming therapy resistance; targeted protein degradation and the ubiquitin-proteasome system; organic synthesis.

https://ostremlab.ucsf.edu

Adam Renslo

[email protected]

Professor in Residence, Pharmaceutical Chemistry

Research summary: Small molecule drug discovery; targeted drug delivery; organic synthesis

https://pharm.ucsf.edu/renslo

Davide Ruggero

[email protected]

Professor, Helen Diller Family Endowed Chair in Basic Research, Urology & Cellular & Molecular Pharmacology

Research summary: Systems level understanding of translation control in cancer: Bridging organismal biology, pharmacology & biochemistry

http://ruggerolab.ucsf.edu/

Andrej Sali

[email protected]

Professor, Bioengineering & Therapeutic Sciences

Research summary: Computation grounded in the laws of physics and evolution to study the structure and function of proteins

http://www.salilab.org/

Jason Sello

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Discovery, design, and synthesis of biologically small molecules and elucidation of their modes of action

Brian Shoichet

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Molecular docking, structure-based inhibitor discovery, G Protein Coupled Receptors, colloidal aggregation and phospholipidosis in drug discovery and formulation, drug discovery for analgesia and psychiatric disorders.

https://bkslab.org/

Kevan Shokat

[email protected]

Professor & Dept. Chair, Cellular & Molecular Pharmacology

Research summary: Chemical tools for studying cellular signaling cascades; protein engineering; organic synthesis.

http://shokatlab.ucsf.edu/

Xiaokun Shu

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Protein engineering, reporter design, drug discovery, cellular and animal imaging, protein liquid-liquid phase separation, visualizing subcellular processes and enzyme activities such as protease, kinase and small GTPase.

https://shulab.ucsf.edu/

Dan Southworth

[email protected]

Associate Professor, Institute for Neurodegenerative Diseases

Research summary: Cryo-electron microscopy and the structure/function of molecular chaperones and AAA+ proteins involved in protein quality control and cell signaling

Katherine Susa

[email protected]

Sandler Fellow, Pharmaceutical Chemistry

Research summary: Mechanisms of transmembrane signaling within the immune system

https://www.susalab.com/

Jack Taunton

[email protected]

Professor, Cellular & Molecular Pharmacology

Research summary: Covalent inhibitors; Natural product mechanisms of action; Chemoproteomics.

https://tauntonlab.ucsf.edu/

Lei Wang

[email protected]

Professor, Pharmaceutical Chemistry & the Cardiovascular Research Institute

Research summary: Design and genetically encode unnatural amino acids for in vivo investigation of cellular signaling and for the development of new biotherapeutics.

https://pharm.ucsf.edu/wang

James Wells

[email protected]

Professor, Pharmaceutical Chemistry

Research summary: Small molecule drug discovery; drug mechanisms as they relate to apoptosis and cancer.

https://pharm.ucsf.edu/wells

Arun Wiita

[email protected]

Assistant Professor, Laboratory Medicine

Research summary: Quantitative proteomics and new therapy development for blood cancers

https://wiitalab.ucsf.edu

Allison Williams

[email protected]

Assistant Professor, Cellular & Molecular Pharmacology

Research summary: Bacterial cell wall nanomachines

https://williamslab.ucsf.edu/

David Wilson

[email protected]

Associate Professor, Radiology, Radiology & Biomedical Imaging

Research summary: Development of metabolism and microenvironment-targeted imaging methods, to guide intervention and predict response to molecular therapies

https://radiology.ucsf.edu/research/labs/wilson

Balyn Zaro

[email protected]

Assistant Professor, Pharmaceutical Chemistry

Research summary: Chemical biology and mass spectrometry-based approach to optimizing drug selectivity and studying the innate immune system and blood formation

https://pharm.ucsf.edu/zaro