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Jason Gestwicki, PhD


Image credit: Elisabeth Fall


Chemistry and Chemical Biology Graduate Program


Institute for Neurodegenerative Diseases

Joint appointments

Faculty affiliations

Graduate program affiliations

Chemistry and Chemical Biology

My research group studies how molecular chaperones maintain protein homeostasis. This question is important because imbalances in protein homeostasis are linked to a number of incurable diseases, including neurodegenerative disorders. Molecular chaperones regulate all aspects of a protein’s lifecycle, including its expression, folding, trafficking and degradation. However, it isn’t yet clear how we might promote the activity of chaperones to cure diseases. Our approach to this question is to develop chemical probes that reveal how chaperones interact with disease-associated proteins.


Mailing/delivery address:
Jason Gestwicki, PhD
CCB Graduate Program Director
675 Nelson Rising Lane, Rm 311, Box 0518
San Francisco, CA 94143

Email: [email protected]
Tel: 415-502-7121
Lab: http://gestwickilab.ucsf.edu