Students

Fifth + Year

Robin Aglietti

UC Santa Cruz

Advisor: John Gross

Research summary: Metal Coordination in the mRNA Decapping Enzyme Dcp2

Daniele Canzio

UC Santa Barbara

Advisor: Geeta Narlikar

Research summary: Chromatin opening by pioneer transcription factors

Jonathan Choy

UC Berkeley

Advisor: Jack Taunton, Adam Renslo

Research summary: Development of potent and specific inhibitors of T.brucei Clk1

Emily Crawford

Bryn Mawr College

Advisor: James Wells

Research summary: Labeling of liberated N-termini for proteome-wide detection and characterization of apoptotic caspase substrates

Nicholas Hertz

UCLA

Advisor: Al Burlingame, Kevan Shokat

Research summary: Mapping Kinase Signaling Pathways using Chemical Genetics and Mass Spectrometry

Jennifer Liu

UC Berkeley

Advisor: Zev Gartner

Research summary: Synthetic Cell Biology: Dissecting signal integration by individual cells within topologically defined microenvironments

Michael Lopez

UC Berkeley

Advisor: David Morgan, Kevan Shokat

Research summary: Development of chemical tools to study the processes of ubiquitination and deubiquitination of substrate proteins

Rebecca Maglathlin

MIT

Advisor: Jack Taunton

Research summary: Development of reversible covalent inhibitors of protein kinases

Rand Miller

Stanford University

Advisor: Jack Taunton

Research summary: Probing the limits and utility of cysteine electrophiles in the context of reversible, covalent small-molecule kinase inhibitors.

Marlisa Pillsbury

San Francisco State University

Advisor: Keith Yamamoto

Research summary: Working towards understanding the mechanism by which the glucocorticoid receptor confers rhythmic expression of circadian rhythm genes

Iana Serafimova

Santa Clara University

Advisor: Jack Taunton

Research summary: Development and mechanism of action of reversible covalent inhibitors that target non catalytic cysteines

Carrie Shiau

UC Berkeley

Advisor: Danica Galonic Fujimori

Research summary: Development of Chemical Probes for Fe(II) and alpha-KG Dioxygenases

Cheryl Tajon

University of San Francisco

Advisor: Charles Craik

Research summary: Proteolytic activation of nanoparticles and devices

Brianna Williams

UCLA

Advisor: Michael Fischbach

Research summary: Characterization of biogenic amine neurotransmitter production by human associated bacteria

Xiu Ming Wong

University of Wisconsin-Madison

Advisor: Lily Jan

Research summary: Structure, function and trafficking of ion channels

Julie Zorn

New York University

Advisor: James Wells

Research summary: Mechanism of Small Molecule Activation of Procaspase-3

Fourth Year

Linh Ho

Uni. of Medcine and Pharmacy at HCMC, VN

Advisor: Eric Verdin

Research summary: Studying the role of SirT4.

Daniel Le

California Polytechnic State University

Advisor: Danica Galonic Fujimori

Research summary: Development of methylarginine analogs to study transcription

Charles Morgan

Lewis and Clark College

Advisor: James Wells

Research summary: Investigating of the cellular biology of crucial caspase substrates using genetic and protein engineering techniques.

Samuel Myers

California Polytechnic State University

Advisor: Al Burlingame

Research summary: Post-translational Modifications of Pluripotency

Idelisse Ortiz Torres

University of Puerto Rico at Rio Piedras

Advisor: Danica Galonic Fujimori

Research summary: Development of mechanism based inhibitor for JmjC-domain-containing histone demethylases.

Megan Riel-Mehan

UC Berkeley

Advisor: Kevan Shokat

Research summary: Designing and using small molecules that selectively crosslink enzyme-substrate pairs in order to find unknown interactions in signaling pathways.

Andrew Wiser

UC Santa Cruz

Advisor: Keith Yamamoto

Research summary: How osteocyte apoptosis is involved in glucocorticoid induced osteoporosis

Third Year

Noel Jee

University of Maryland

Advisor: Zev Gartner

Research summary: Complementing the current technologies used in the Gartner Lab for the programmed assembly of mammary cells, with novel methods involving a lipid-based approach.

Joel Karpiak

Advisor: Brian Shoichet

Research summary: Computational methods for the discovery of novel G protein-coupled receptor drugs and experimentally determining and verifying their mechanism of action.

Melody Lee

UC Berkeley

Advisor: Charles Craik

Research summary: Engineering antibody inhibitors from biased immune repertoires to study cancer-related proteases and disease-associated pathophysiology

Aaron Mendez

Advisor: Peter Walter, Kevan Shokat

Research summary: Developing selective activators of protein kinase IRE1 to better understand its mode of activation and relevance in human disease.

Crystal Nyitray

UC Santa Cruz

Advisor: Tejal Desai

Research summary: Constructing 3-D Beta Cell Clusters for Insulin Secretion

Jonathan Ostrem

UC San Diego

Advisor: Kevan Shokat

Research summary: Development of a selective inhibitor of oncogenic K-Ras.

Justin Rettenmaier

UC Santa Cruz

Advisor: James Wells

Research summary: Small-molecule activation of protein kinases with allosteric ligands

Amanda Silber

Colorado College

Advisor: Jack Taunton

Research summary: Mechanistic study of the spatiotemporal activation of PI3K by upstream activators

Second Year

Brittany Gulledge

University of North Carolina at Chapel Hill

Advisor: Natalia Jura

Research summary: Investigating the interaction between HER3 and PI3K using biochemical and biophysical techniques

Yi-Chang Liu

National Yang-Ming University

Advisor: Danica Galonic Fujimori, Jonathan Weissman

Research summary: Investigation of the early process in recognizing misfolded proteins in endoplasmic reticulum

Christopher Novotny

University of Illinois Urbana-Champaign

Advisor: Kevan Shokat

Research summary: Investigating the effects of EGFR family inhibitors, and Development of a Specific LRRK2 inhibitor

Florentine Rutaganira

University of California, Davis

Advisor: Kevan Shokat

Research summary: Development of small molecules to inhibit lipid kinases and modulate host-pathogen interactions.

Jessica Thomaston

Advisor: Bill DeGrado

Hai Tran

Emory University

Advisor: James Wells

Research summary: Display of Natural Products

Christopher Williams

Grinnell College

Advisor: Jonathan Weissman

Research summary: Genome-wide investigation of localized translation within cells and tissues using modified ribosome profiling methodology.

First Year

Jordan Carelli

University of Puget Sound, University of California, Berkeley

Marian Deuker

Williams College

Christina Fitzsimmons

Macalester College

Louise Goupil

University of California at Berkeley

Amy Jacobson

Stanford University

Advisor: Michael Fischbach

Rebecca Levin

Princeton University

Justin Meyerowitz

Haverford College

Advisor: Kevan Shokat, William Weiss

Nicole Olson

California Polytechnic State University - San Luis Obispo

Katherine Southard

Rensselaer Polytechnic Institute

Benjamin Spangler

Goucher College

Sarah Woldemariam

Case Western Reserve University

Rahel Woldeyes

University of Minnesota - Twin Cities, University of Minnesota - Twin Cities

Naomi Yonis

Scripps College

Noah Younger

University of Chicago

Advisor: Danica Galonic Fujimori